Serious lab allergies from peptide coupling agents

The Journal of Organic Chemistry is reporting a case of severe allergic reactions (i.e., life-threatening anaphylaxis) developed to reagents used for peptide coupling (assembling short proteins). Any lab worker using HATU, HBTU, or HCTU, three uronium coupling agents, should read this link and speak with his or her PI regarding any necessary changes to use protocols. Also please contact Dan Kuespert, Homewood Laboratory Safety Advocate, for assistance.

(J. Org. Chem. 2019, DOI: 10.1021/acs.joc.9b03280)

by Daniel Kuespert

Laboratory Safety Advocate for the Johns Hopkins University Homewood Campus. I am a Ph.D. chemical engineer and Certified Safety Professional with experience in industrial research, nonprofit management, and chemical safety consulting. My role is to promote a culture of safety at Homewood by working with faculty, staff, and students to bring safety expertise into the laboratory.